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HKU Medicine x Science Keynote Lecture: The Piwi-piRNA Pathway: a New World of Genetic Regulation in the Germline
Small non-coding RNAs play key roles in gene regulation. In 1998, Professor Lin discovered the argonaute (ago) gene family that encodes key proteins of small RNA pathways and are essential for stem cell self-renewal in both animal and plant kingdoms. Within this gene family, the ago subfamily is ubiquitously expressed. Ago proteins bind to siRNA and miRNA (mostly 21 nucleotides in length) and function in the RNAi and miRNA pathways.
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